Certified Dialysis Nurse Practice Test 2026 – All-in-One Resource for Exam Success!

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How does the body adapt to decreased kidney function in chronic kidney disease?

By decreasing blood flow to the kidneys

By increasing the workload of remaining nephrons and activating hormonal systems

In chronic kidney disease, the body compensates for decreased kidney function primarily by increasing the workload of the remaining functional nephrons and activating various hormonal systems. As kidney function diminishes, not all nephrons are affected equally. The nephrons that remain functional take on a greater burden to filter blood and maintain homeostasis.

To manage the loss of filtering capacity, the body stimulates the renin-angiotensin-aldosterone system (RAAS), which helps to regulate blood pressure and electrolyte balance. This hormonal response contributes to changes in blood flow dynamics, allowing the remaining nephrons to adjust their function and compensate for those that are impaired.

This adaptation is a critical response to the gradual loss of kidney function in chronic conditions, enabling individuals to sustain some level of renal function and metabolic balance for an extended period, despite the underlying disease process.

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By shutting down the renal system completely

By maintaining a consistent filtration rate

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